HUMANIZED SUBSTITUTIONS OF VMAT1 IN MICE ALTER AMYGDALA-DEPENDENT BEHAVIORS ASSOCIATED WITH THE EVOLUTION OF ANXIETY

Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

Summary: The human vesicular monoamine transporter 1 (VMAT1) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles.These substitutions are absent in all known mammals, suggesting their contributions to distinct aspects of human behavior modulated by monoaminergic transmissions, such as emotion and cognitio

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